Analysis of Post-Translational Modifications of a Critical Protein Implicated in Amyotrophic Lateral Sclerosis

Completed

Conditions studied: ALS

In brief

The purpose of this research study is to discover and quantitate the differences in post-translational modifications found in the Cu, Zn superoxide dismutase (SOD1) of patients with amyotrophic lateral sclerosis (ALS) as compared to healthy individuals. SOD1 is a known genetic cause of ALS. With certain mutations, SOD1 gains a toxic function which leads to motor neuron death.

Key facts

Study ID

NCT02228915

Run by

University of North Carolina, Chapel Hill

People needed

21

Starts

2014-08-01

Expected to finish

2018-10-16

Last updated by the study team

2018-10-17

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• SALS patients
• SOD1 associated FALS patients
• Healthy control
• Exclusion Criteria: none

Where it is running

• UNC Neurology ALS clinic — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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