Perioperative Anticoagulant Use for Surgery Evaluation Study
Completed
Conditions studied: Atrial Fibrillation
In brief
The aim of the Perioperative Anticoagulant Use for Surgery Evaluation (PAUSE) Study, is to establish a safe, standardized protocol for the perioperative management of patients with atrial fibrillation (AF) who are receiving a novel oral anticoagulant (DOAC) drug, either dabigatran, rivaroxaban or apixaban, and require an elective surgery/procedure.
Key facts
- Study ID
- NCT02228798
- Run by
- McMaster University
- People needed
- 3135
- Starts
- 2014-08-01
- Expected to finish
- 2018-08-31
- Last updated by the study team
- 2019-06-28
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 years or older
- Receiving a DOAC (dabigatran or rivaroxaban or apixaban) for Atrial Fibrillation
- Ability to assess patient at lease one day prior to DOAC discontinuation
You may not qualify if…
- CrCl less than 30 mL per min for dabigatran- and rivaroxaban-treated patients ( less than 25 mL per min for apixaban-treated patients) as estimated by Cockroft-Gault formula
- Cognitive impairment or psychiatric illness that precludes collection of followup data
- Inability or unwillingness to provide informed consent
Where it is running
- Department of Pharmacy, Kaiser Permanente Colorado, Aurora, CO, USA — Aurora, Colorado, United States
- NorthShore University HealthSystem — Evanston, Illinois, United States
- Henry Ford Health System — Detroit, Michigan, United States
- Department of Cardiovascular Sciences, University of Leuven — Leuven, Belgium
- University of Alberta — Edmonton, Alberta, Canada
- Vancouver General Hospital — Vancouver, British Columbia, Canada
- QEII Hospital — Halifax, Nova Scotia, Canada
- Hamilton General Hospital — Hamilton, Ontario, Canada
- Juravinski Hospital — Hamilton, Ontario, Canada
- McMaster University Medical Centre — Hamilton, Ontario, Canada
- St. Joseph's Healthcare — Hamilton, Ontario, Canada
- The Ottawa Hospital — Ottawa, Ontario, Canada
- North York General — Toronto, Ontario, Canada
- Toronto General Hospital — Toronto, Ontario, Canada
- University of Manitoba — Winnipeg, Ontario, Canada
- Maisonneuve-Rosemont — Montreal, Quebec, Canada
- Montreal General Hospital — Montreal, Quebec, Canada
- Montreal Jewish General Hospital — Montreal, Quebec, Canada
- St. Mary's Hospital — Montreal, Quebec, Canada
- Department of Anesthesiology, University of Thessaly — Larissa, Greece
- Department of Vascular Medicine, Amsterdam Cardiovascular Sciences — Amsterdam, Netherlands
Full record on ClinicalTrials.gov
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