A Study of Evacetrapib (LY2484595) in Participants With High Cholesterol

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Hyperlipidemia

In brief

The purpose of the ACCENTUATE study is to evaluate whether the study drug known as evacetrapib is effective in treating participants with high cholesterol and atherosclerotic cardiovascular disease (ASCVD) and/or diabetes.

Key facts

Study ID

NCT02227784

Run by

Eli Lilly and Company

People needed

366

Starts

2014-10-01

Expected to finish

2015-12-01

Last updated by the study team

2019-10-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must be treated with atorvastatin 40 mg/day for at least 30 days prior to screening
• Have an LDL-C >70 mg/deciliter(dL) or non-HDL-C >100 mg/dL
• Have screening triglycerides ≤400 mg/dL (≤4.5 millimoles/Liter)
• Individuals with ASCVD and/or individuals with type 1 or type 2 diabetes

You may not qualify if…

• Have a hemoglobin A1c (HbA1c) >9.5%
• New York Heart Association (NYHA) class III or IV congestive heart failure
• History of either a transient ischemic stroke or ischemic stroke <30 days
• History of acute coronary syndrome (ACS) <30 days

Where it is running

• Desert Clinical Research — Mesa, Arizona, United States
• Central Phoenix Med Clinic LLC — Phoenix, Arizona, United States
• Advanced Clinical Research — Carmichael, California, United States
• Tooraj Joseph Raoof M.D., Inc. — Encino, California, United States
• Irvine Clinical Research Center — Irvine, California, United States
• VA Long Beach Healthcare System — Long Beach, California, United States
• Rancho Cucamonga Clinical — Rancho Cucamonga, California, United States
• Encompass Clinical Research — Spring Valley, California, United States
• University Clinical Investigators, Inc. — Tustin, California, United States
• Diablo Clinical Research — Walnut Creek, California, United States
• University of Colorado Health Sciences Center — Aurora, Colorado, United States
• Cardiac Research — Colorado Springs, Colorado, United States
• ZASA Clinical Research — Boynton Beach, Florida, United States
• Cardiology Research Assoc. — Daytona Beach, Florida, United States
• Avail Clinical Research LLC — DeLand, Florida, United States
• Alan Graff, MD, PA — Fort Lauderdale, Florida, United States
• Nature Coast Clinical Research, LLC — Inverness, Florida, United States
• Suncoast Research Group, LLC — Miami, Florida, United States
• Progressive Medical Research — Port Orange, Florida, United States
• Cardiology Partners Clinical Research Institute, LLC — Wellington, Florida, United States
• Georgia Heart Specialists — Covington, Georgia, United States
• United Osteoporosis Center — Gainesville, Georgia, United States
• East West Medical Institute — Honolulu, Hawaii, United States
• Solaris Clinical Research — Meridian, Idaho, United States
• Heart Center Research, LLC — Huntsville, Alabama, United States

Full record on ClinicalTrials.gov

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