Treatment for Teens With Alcohol Abuse and Depression

Completed · Not applicable

Conditions studied: AOD Use, Abuse, and Dependence, Depression

In brief

The investigators will recruit adolescents with alcohol or cannabis abuse and clinically significant depression. All participants will receive 12 sessions of an evidence-based treatment for alcohol abuse, Motivation Enhancement Therapy/Cognitive Behavior Therapy-12, over 12 to 14 weeks. Those who are still depressed after 4 weeks will be randomized to receive treatment augmentation with either an integrated cognitive behavior therapy for depression, delivered by their study therapist, or depression treatment-as-usual in the community. The study hypothesis is that integrated depression treatment will surpass community treatment-as-usual in efficacy.

Key facts

Study ID

NCT02227589

Run by

Duke University

People needed

103

Starts

2015-01-16

Expected to finish

2020-01-03

Last updated by the study team

2020-02-05

Who can join

Age: 13 and older, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 13 years to 21 years, 11 months at baseline
• Current alcohol or cannabis abuse or dependence diagnosis (DSM-IV) OR current level of potentially harmful drinking or cannabis use as evidenced by (1) consumption of 4 or more drinks per drinking day (males) or three or more (females), or use of cannabis at least three times in past 90 days (or before admission into a controlled environment)
• Current clinically significant depression, defined as a score of 40 or more on the Children's Depression Rating Scale-Revised at baseline
• If currently taking anti-depressant medication, on a stable dose for at least one month
• Willingness to accept treatment
• Able to speak and read English (5th-grade level)
• Residence within 45-minute drive from treatment site
• Adolescent and a parent agree to sign Institutional Review Board approved consent/assent form; for subjects ages 18-19, parent involvement is optional and is the decision of the youth
• Parent/guardian agrees to provide collateral information and to designate two third parties who could be contacted in case the subject is lost to follow-up; for subjects ages 18-19, the participating youth will provide this information
• Participant (and parent, if youth is under age 18) not planning to move outside the area in the next 9 months.

You may not qualify if…

• Suicidal ideation with a plan, or suicide attempt within 30 days. In addition to such suicide risk being indicated in baseline interview material, a score exceeding the 89th percentile on the Suicide Ideation Questionnaire (SIQ-Jr), will necessitate an immediate risk assessment by the Independent Evaluator which may lead to exclusion under this criterion.
• Homicidal ideation with a plan or any plan to hurt others
• Lifetime diagnosis of psychosis, schizophrenia, bipolar disorder, intellectual disability or autistic disorder
• Current dependence on a substance other than alcohol, marijuana or nicotine
• Current non-alcohol or cannabis use disorder or depression primary diagnosis, i.e., the diagnosis requires care more urgently than does alcohol or cannabis use disorder or depression

Where it is running

• University of Connecticut Health Center — Farmington, Connecticut, United States
• Duke Child and Family Study Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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