Study of Retinal Findings in People With Signs and Symptoms of Alzheimer s Disease Enrolled in 09-M-0198
Stopped early
Conditions studied: Age-Related Macular Degeneration, Alzheiner's Disease, AMD
In brief
Background: \- Alzheimer s disease affects the brain and causes memory and thinking problems in older people. Macular degeneration (MD) is an eye condition. It is the leading reason that people over age 55 in the United States lose their central vision. Central vision is important for seeing fine details and for tasks like reading and driving. A feature of Alzheimer s disease is plaques in the brain. A feature of age-related MD is deposits in the retina in the eye. Researchers want to learn more about these diseases and find out if they are related. Objective: \- To see whether there is a relationship between Alzheimer s disease and age-related macular degeneration. Eligibility: \- People with or without Alzheimer s disease enrolled in another study. Participants must have someone to help them take part in this study. Design: * Participants will be screened through the other study. They will have 1 visit. The tests will take about 3 hours. * Participants will answer questions about their medical and eye history. * Participants will have an eye exam to test how well they see. Their eye pressure will be measured and their eye movements will be checked. * Participants will get eye drops to dilate their pupils. Researchers will take pictures of the retina and the inside of the eye. Researchers may measure the thickness of the retina. * Participants will continue to receive care from their regular eye doctor during and after the study.
Key facts
- Study ID
- NCT02226835
- Run by
- National Eye Institute (NEI)
- People needed
- 33
- Starts
- 2014-08-13
- Expected to finish
- 2017-01-24
- Last updated by the study team
- 2018-09-27
Who can join
Age: 45 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Patients:
- The diagnosis of a different type of dementia, including frontotemporal dementia, normal pressure hydrocephalus, Lewy body dementia, Parkinson s disease dementia, Huntington s disease, or vascular dementia.
- Any medical contraindication to the procedures performed in the study, or any current severe medical or psychiatric illness other than Alzheimer s disease.
- Behavioral symptoms that would preclude the gathering of data for the study, or advanced disease such that participants cannot provide assent.
- Controls:
- The diagnosis of a brain disorder.
- Any medical contraindication to the procedures performed in the study, or any current severe medical or psychiatric illness.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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