Uncovering the 'ORIGINS' of Diabetes

Completed

Conditions studied: Type 2 Diabetes

In brief

This is a study to identify different subtypes of type 2 diabetes. The investigators will look for information at the molecular level, which may lead to personalized diagnosis and therapies.

Key facts

Study ID

NCT02226640

Run by

AdventHealth Translational Research Institute

People needed

80

Starts

2010-11-01

Expected to finish

2014-06-01

Last updated by the study team

2018-02-22

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age > 18
• HbA1C < 8.0% *
• You have not gained or lost more than 3 kg or 6.6 pounds in the last 8 weeks
• You have not lost more than 10% of your heaviest body weight in your lifetime
• BMI < 25 kg/m2 or > 30 kg/m2
• Women: more than 1 year post-partum
• Have diabetes and are able to maintain accurate and reliable home glucose monitoring logs

You may not qualify if…

• Treatment with more than 2 of the following: metformin (Fortamet, Glucophage, Glumetza, Riomet), sulfonylureas (Glucotrol, Diabeta, Glynase, Micronase), Glucagon-like peptide-1 analogs (Byetta) and/or Dipeptidyl peptidase IV inhibitors (Januvia, Onglyza)
• Treatment with long acting Glucagon-like peptide-1 agonists within the last 3 months (i.e. exenatide once weekly)
• Treatment with thiazolidinediones (TZDs) (i.e. Avandia, Actos, Rezulin) within the last 3 months
• Known, untreated thyroid disease or abnormal thyroid function blood test.*
• Known diagnosis of liver disease (except NASH) or elevated liver function blood test
• Known diagnosis of kidney disease or elevated kidney function blood test
• Uncontrolled high blood pressure (BP > 140 systolic or > 90 diastolic)
• Start of or changes in oral contraceptives or hormone replacement therapy within the last 3 months
• Use of drugs or alcohol (> 3 drinks per day) within the last 5 years.
• Uncontrolled psychiatric disease that would interfere with study participation.
• History of cancer within the last 5 years (skin cancers, with the exception of melanoma, may be acceptable)
• History of organ transplant
• History of heart attack within the last 6 months
• Current treatment with blood thinners or antiplatelet medications that cannot be safely stopped for testing procedures
• Current anemia
• History of HIV, active Hepatitis B or C, or Tuberculosis
• Presence of clinically significant abnormalities on electrocardiogram.
• Current smokers (smoking any nicotine or non-nicotine product within the past 3 months)
• Use of any medications known to influence glucose, fat and/or energy metabolism within the last 3 months (e.g., growth hormone therapy, glucocorticoids [steroids], etc.)

Where it is running

• Translational Research Institute for Metabolism and Diabetes — Orlando, Florida, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.