Aprepitant to Mitigate Opioids' Cognitive Side Effects

Status unconfirmed · Not applicable · Has a placebo group

Conditions studied: Cognitive Dysfunction

In brief

Morphine and similar substances (called opioids) are often prescribed for moderate to severe pain, such as after a surgery, thus allowing for minimal pain and a better recovery. Unfortunately various, non-dangerous side effects from opioids occur often that limit the way patients feel and can take of themselves, despite otherwise good pain control and minimal limitations from the surgery itself.

Key facts

Study ID

NCT02226601

Run by

University of Arizona

People needed

50

Starts

2014-10-01

Last updated by the study team

2015-06-02

Who can join

Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy English speaking, opioid-naive consenting adults

You may not qualify if…

• current or very recent (< 3 months) opioid therapy
• morbid obesity
• liver disease
• therapy with pimozide, terfenadine, astemizole, cisapride, vitamin K antagonists (warfarin), hormonal contraceptives
• acute or chronic infections
• immunocompromised status
• hemodynamically unstable, hemorrhage (bleeding)
• recent surgery
• pregnancy, nursing
• younger than 18 years old
• not proficient of the English language

Where it is running

• University of Arizona Medical Center — Tucson, Arizona, United States (enrolling)

Full record on ClinicalTrials.gov

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