Effect of Intense Training on Ovarian Function and Bone Turnover

Completed · Not applicable

Conditions studied: Amenorrhea

In brief

The investigators propose a prospective, longitudinal, department funded study protocol to evaluate whether changes in energy availability, during a period of highly intensified exercise training, will increase bone turnover markers and decrease ovarian function and exercise performance, in a dose-dependent fashion in competitive female athletes.

Key facts

Study ID

NCT02224976

Run by

USDA, Western Human Nutrition Research Center

People needed

18

Starts

2014-01-01

Expected to finish

2015-12-01

Last updated by the study team

2016-01-28

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• competitive endurance runners (racing in events ranging from 10km to ultra-marathons)
• training at least 5 days per week over the past 12 months, and more than 30 miles per week
• regular menstrual cycles (24-35 days) over the past 6 months
• maximal oxygen consumption (VO2max) > 50ml/kg/min
• English speaking

You may not qualify if…

• smoker
• amenorrhea
• pregnant or lactating in the past 2 years
• chronic disease that will affect bone health, metabolism or the cardiorespiratory system
• take medications that have cardiovascular or metabolic effects
• present any contra-indication to exercise testing (cardiovascular abnormalities)
• report any major illness or injury preventing training for more than 4 weeks over the past 3 months
• a history of clinical anorexia nervosa or bulimia nervosa

Where it is running

• USDA Western Human Nutrition Research Center — Davis, California, United States

Full record on ClinicalTrials.gov

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