Psychosis and Affective Research Domains and Intermediate Phenotypes
Completed
Conditions studied: Bipolar I Disorder, Unspecified, With Psychotic Features, Bipolar I Disorder, Unspecified, Without Psychotic Features
In brief
The objective of this multi-site research collaboration is to test the manifestation and distribution of biological markers for psychosis and affect dimensions across the schizophrenia/bipolar (SZ-BD) diagnostic boundary, and to examine heritability and genetic associations for these biological markers.
Key facts
- Study ID
- NCT02218853
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 113
- Starts
- 2014-04-01
- Expected to finish
- 2017-12-01
- Last updated by the study team
- 2019-09-19
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Must provide consent to participate after being fully informed about the study procedures and the information to be collected
- Males and females
- Ages 18-60 years old
- All races and ethnicities
- Probands: Must meet DSM-IV criteria for bipolar I disorder with or without lifetime history of psychosis; Healthy Controls: Must have no personal history of any psychotic or mood disorder, or a family history of psychotic or recurrent mood disorder among their first-degree relatives
- Must be judged to be capable of completing the study procedures by study investigators
- Must be able to read, speak, and understand English
You may not qualify if…
- An estimated IQ<70
- Major neurological or cognitive disorder (e.g., seizure disorder, traumatic brain injury, cerebrovascular disease, pervasive developmental disorder)
- Serious medical, neuro-ophthalmological, or neurological illness that could affect CNS functioning (e.g., decompensated cardiovascular disease, decompensated chronic obstructive pulmonary disease, late stages of diabetes, AIDS)
- DSM-IV diagnosis of alcohol or illicit substance abuse within 1 month, or alcohol or substance dependence within 3 months, or extensive history of past substance use
- Women who are pregnant (due to unknown risks related to MRI exposure)
- Presence of medical (e.g., artificial joints, brain aneurism clips, surgical pins, rods, wires, implants) or non-medical (e.g., metal piercing) irremovable metallic objects on/inside body (due to MRI-relevant risks)
Where it is running
- UT Southwestern Medical Center — Dallas, Texas, United States
Full record on ClinicalTrials.gov
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