Use of Inhaled Nitric Oxide to Prevent Pulmonary Hypertension Associated to Stored Blood Transfusion

Withdrawn before enrolling · Phase 2

Conditions studied: Hypertension, Pulmonary, Hemolysis

In brief

The objective of this study is to assess if prolonged storage time of a packed red blood cell unit may cause pulmonary vasoconstriction after transfusion, in a susceptible population such as cardiac surgery patients. The investigators will also evaluate the potential reversal effect of Inhaled Nitric Oxide on pulmonary vasoconstriction induced by stored blood transfusions.

Key facts

Study ID

NCT02217683

Run by

Massachusetts General Hospital

People needed

0

Starts

2016-03-01

Expected to finish

2017-04-01

Last updated by the study team

2016-03-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Provide written informed consent
• Elective cardiac or aortic surgery
• One or more blood transfusions scheduled for clinical reasons
• Presence of an arterial catheter and pulmonary arterial catheter

You may not qualify if…

• Emergent cardiac surgery.
• Patients requiring irradiated or washed blood transfusions.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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