Assessing the Efficacy of Intravenous Acetaminophen Versus the Oral Formulation for Perioperative Pain Treatment

Completed

Conditions studied: Postoperative Pain

In brief

To compare oral (PO) to intravenous (IV) acetaminophen with postoperative pain scores, and consumptions of opiates, among orthopedic surgery patients undergoing total knee replacement with spinal anesthesia. Our hypothesis is that IV acetaminophen patients will have improved analgesia, less opioid consumption, a lower percentage of patients rescuing, or a longer time to first rescue with IV acetaminophen. The investigators will compare the efficacies of oral and intravenous acetaminophen for postoperative pain control, and utilization of opiates as rescue agents.

Key facts

Study ID

NCT02216682

Run by

Massachusetts General Hospital

People needed

174

Starts

2014-08-01

Expected to finish

2017-12-01

Last updated by the study team

2026-06-15

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients undergoing total knee replacement
• Successful spinal placement
• ≥18 years old

You may not qualify if…

• Failed spinal anesthesia
• Chronic opiate users
• Liver disease patients
• Allergy/hypersensitivity to acetaminophen
• Patients with baseline dementia
• Patients weighing less than 50kg, history of alcohol dependence, renal impairment, opiate allergy, and pregnancy.

Where it is running

• Massachusetts General Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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