Improving Memory Performance by Applying Cognitive Training
Completed · Not applicable
Conditions studied: HIV
In brief
The proposed study will test the efficacy of a cognitive training program to improve working memory in a sample of HIV-infected persons. Investigators will assign 40 HIV-infected adults with poor medication adherence to one of two conditions (20/group): the experimental cognitive training intervention or a control training condition. Participants will complete 12 training sessions across 10 weeks and will complete assessments at baseline and post-training. The specific aims are to: 1. Investigate the effects of the cognitive training intervention on working memory and delay discounting in HIV-infected persons. Hypothesis 1: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in working memory and reductions in delay discounting. 2. Characterize adherence to antiretroviral medications in this population and examine medication adherence after cognitive training. Hypothesis 2: Participants assigned to active cognitive training, compared to those in the attention-matched control group, will have greater improvements in medication adherence.
Key facts
- Study ID
- NCT02216591
- Run by
- Duke University
- People needed
- 33
- Starts
- 2014-08-01
- Expected to finish
- 2016-06-29
- Last updated by the study team
- 2017-06-28
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- HIV infection, diagnosed for > 6 months
- Currently on treatment with antiretroviral medications for > 3 months
- Self-reported medication adherence at less than 90%
- Lives within 15 miles of the research site in stable housing and with no plans to move from the area in the next 3 months
You may not qualify if…
- Current substance use disorder
- Any drug use other than alcohol or marijuana in the past year
- Pregnancy
- English non-fluency or illiteracy
- ≤ 8th grade education
- serious neurological disorders, including HIV dementia
- traumatic brain injury
- severe mental illness or acute psychiatric distress
- impaired mental status
Where it is running
- Duke University Medical Center — Durham, North Carolina, United States
Full record on ClinicalTrials.gov
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