Molecular Testing of Cancer by Integrated Genomic, Transcriptomic, and Proteomic Analysis

Status unconfirmed

Conditions studied: Solid Tumors, Hematological Malignancies

In brief

The purpose of this study is to discover genetic changes associated with different cancers. With the information from this study the investigators hope to provide better ways to prevent, detect and treat many cancers. Many diseases can result from changes in a person's genetic material that causes cells to not work properly. Currently, researchers and doctors know some of the genetic changes that can cause disease, but they do not know all of the genetic changes that can cause disease. This project is designed to identify genetic changes that can cause cancer in humans. Specimens will be collected from a scheduled diagnostic or routine (i.e. blood draw for counts) procedure and may include samples from the tissue itself (surgery), bone marrow, blood, saliva, urine, spinal fluid, sputum, joint fluid, seminal fluid, ascites (a fluid that fills up in the abdomen), and/or pleural fluid (fluid in the lung cavity), to either confirm the diagnosis of cancer or to help to decide how best to treat cancer or other illness. Additionally archived tissue may be analyzed. Samples may be stored for future use in later experiments. The Department of Pathology at Rhode Island Hospital will store the samples. Information from the medical record, such as responses to treatments or family history of cancer, will be collected.

Key facts

Study ID

NCT02213822

Run by

Rhode Island Hospital

People needed

500

Starts

2013-05-01

Expected to finish

2015-08-01

Last updated by the study team

2014-08-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Documented informed consent
• Patient has either a suspected or confirmed solid tumor or hematological malignancy
• There is enough tissue or body fluid to allow for experimental study
• The patient is over the age of 18

You may not qualify if…

• The patient is unwilling or unable to provide informed consent

Where it is running

• Rhode Island Comprehensive Cancer Center at East Greenwich — East Greenwich, Rhode Island, United States (enrolling)
• Rhode Island Hospital — Providence, Rhode Island, United States (enrolling)
• The Miriam Hospital — Providence, Rhode Island, United States (enrolling)

Full record on ClinicalTrials.gov

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