Effects of Walnuts on Central Blood Pressure, Arterial Stiffness Indices, Lipoproteins, and Other CVD Risk Factors
Completed · Not applicable
Conditions studied: Cardiovascular Disease
In brief
This study will evaluate the effects of walnut-derived ALA and bioactives on multiple CVD risk factors, including central blood pressure, arterial stiffness indices, inflammatory markers, urinary isoprostanes, vascular adhesion markers, and changes in lipids and lipoproteins. Gut microbiome changes due to walnut consumption will also be assessed using the 16S rRNA gene.
Key facts
- Study ID
- NCT02210767
- Run by
- Penn State University
- People needed
- 46
- Starts
- 2014-08-01
- Expected to finish
- 2018-04-01
- Last updated by the study team
- 2023-08-21
Who can join
Age: 30 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Aged 30-65 years
- BMI greater than 25 and less than or equal to 40 kg/m2
- Non-smokers
- TG < 350 mg/dL
- LDL-C between the 25-95th percentile from NHANES:
- Males: 105-194 mg/dL
- Females: 98-190 mg/dL
- Stage I hypertension:
- SBP > 120 mmHg and/or DBP > 80 mmHg
- SBP < 160 mmHg and DBP < 100 mmHg
- Free of established CVD, stroke, diabetes, liver, kidney or autoimmune disease.
You may not qualify if…
- Elevated BP (SBP ≥160 mmHg OR DBP ≥ 100 mmHg)
- A history of myocardial infarction, stroke, diabetes mellitus, liver disease, inflammatory disease, kidney disease, and/or thyroid disease (unless controlled on medication).
- Blood pressure or cholesterol-lowering medication use
- Refusal to discontinue intake of putative cholesterol-lowering supplements (psyllium, fish oil capsules, soy lecithin, niacin, fiber, flax, and phytoestrogens).
- Vegetarianism or other dietary practices that are inconsistent with the test diets
- Nut allergies (Other food allergies will be reviewed on a case-by-case basis)
- Refusal to discontinue nutritional supplements, herbs, vitamins or NSAID's
- Latex allergy
- Pregnant or lactating females
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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