APIC-CF Therapy for Mild to Moderate Osteoarthritis of the Knee

Status unconfirmed · Phase 1/Phase 2 · Has a placebo group

Conditions studied: Pain, Osteoarthritis

In brief

The mechanism of Osteoarthritis (OA) is complex, however the investigators know that cartilage breakdown follows changes in certain cells in the cartilage called chondrocytes, leading to proteases that break down cartilage. There is a protein in the human blood called alpha-2-macroglobulin that can trap these proteases and prevent the breakdown of cartilage. Cytonics developed a device that use the patient's own blood to remove all cells and concentrate alpha-2-macroglobulin to be injected in the painful knee due to osteoarthritis.

Key facts

Study ID

NCT02210468

Run by

Cytonics Corporation

People needed

300

Starts

2015-05-01

Expected to finish

2016-12-01

Last updated by the study team

2015-08-21

Who can join

Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The patient provides signed written informed consent
• The patient is willing and able to complete effectiveness and safety questionnaires and is able to read and understand study instructions in English.
• Patient is a male or female aged between 21 - 70 years of age at the time of informed consent.
• Patient is ambulatory (assistive devices allowed if used 4 weeks or more prior to Screening).
• Patient has symptomatic OA in the target knee
• Patient has a radiographic confirmation of OA at the target knee prior to screening with a grade II or III score on the K-L grading scale (Kellgren, 1957)using radiographs performed within 24 weeks of Screening
• The patient has knee pain as demonstrated by a score of ≤3 on the KOOS pain subscale
• The patient has venous access sufficient for APIC-CF production

You may not qualify if…

• The patient has any of the following:
• Grade 4 score on the K-L grading scale for the target knee
• Grade 3 score on the K-L grading scale and exhibits at least one Grade 4 characteristic (large osteophytes, marked narrowing of joint space, severe sclerosis, or definite deformity of bone contour).
• Acute fracture of the lower limb.
• Medical history of severe bone disease (e.g., osteoporosis, osteonecrosis, joint deformity, instability, or septic arthritis).
• The patient is categorized as grossly obese, defined as body mass index (BMI) greater than 35 kg/m2
• Hemoglobin values <11 g/dL
• Pregnant or breastfeeding women
• Has clinically apparent tense effusion of the target knee.
• Has had chondrocyte transplantation or reconstruction of ligaments in the target knee.
• Has received an intra-articular injection(s) into any joint (e.g., corticosteroids or chondroprotective agents) within 60 days prior to Screening. Subjects receiving a corticosteroid injection during the study will be withdrawn from the study.
• Has had surgery to the target knee within 12 months or arthroscopy of the target knee within 90 days prior to Screening.
• Has an inflammatory disease of either knee other than OA (e.g., rheumatoid arthri septic arthritis).
• Has another disease that can affect the health of the knee (e.g., chronic hemochromatosis; sickle cell anemia; arthropathies of systemic diseases such as chondrocalcinosis, gout, pseudogout, psoriasis, hemophilia, and infectious diseases of the joints).
• Has significant joint infection in the target knee or inflammatory or skin disorder in the injection area of the target knee.
• Septic arthritis in any joints within 1 year prior to screening;
• Has fibromyalgia, anserine bursitis, lumbar radiculopathy, neurogenic or vascular claudication, vascular insufficiency of lower limbs, or peripheral neuropathy severe enough to interfere with the study evaluations.
• Patella femoral instability
• Patients with a history of cartilage allograft, autograft or microfracture in the study knee
• Patients with a history of any type of blood coagulation or bleeding disorder, currently taking warfarin or other parental anticoagulant therapy or history of DVT/PE during <1 year of Screening.
• Has a systemic or other disease or significant liver function test result from screening that, in the opinion of the investigator, would interfere with study evaluation or have an impact on the balance of benefits and risks of study treatment.
• Diseases that may interfere:
• type 1 diabetes
• immunodeficiency syndrome
• significant cardiovascular, renal, or liver disease

Where it is running

• IRC Clinical — Townsend, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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