Pharmacological Treatment of Comorbid Alcohol and Marijuana Withdrawal and Dependence
Completed · Phase 2 · Has a placebo group
Conditions studied: Cannabis Dependence, Alcohol Dependence, Cannabis Use Disorder, Alcohol Use Disorder
In brief
The primary aim of the supplemental study is to provide POC testing of aprepitant as a treatment for comorbid alcohol and cannabis dependence. The data analysis plan specified in the parent grant will likewise be applied to the supplemental project to test for effects of aprepitant vs placebo on measures of alcohol and cannabis use and protracted withdrawal. The primary hypothesis is that subjects treated with aprepitant will have significantly less alcohol and marijuana use than subjects treated with placebo.
Key facts
- Study ID
- NCT02210195
- Run by
- The Scripps Research Institute
- People needed
- 20
- Starts
- 2014-09-04
- Expected to finish
- 2016-12-19
- Last updated by the study team
- 2017-08-02
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Males or females from 18-70 years of age
- Meets DSM IV criteria for current alcohol and cannabis dependence
- Seeking research-based outpatient treatment for alcohol and cannabis dependence that involves daily oral medication
- Negative BAC and a CIWA score < 9 at randomization
You may not qualify if…
- Significant medical disorders or use of medications that will increase potential risk or influence study outcomes
- Females who are pregnant, nursing or who are sexually active with child-bearing potential and refuse to use an effective, non hormonal method of birth control during the study and for up to 4 weeks after study termination• Treatment with an investigational drug during the previous month
- Prior treatment with NK1 antagonists
- Participants for whom treatment is being mandated by a legal authority• Inability to understand and/or comply with the provisions of the protocol and consent form
Where it is running
- The Scripps Research Institute — La Jolla, California, United States
Full record on ClinicalTrials.gov
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