Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients

Stopped early

Conditions studied: Meningoencephalitis, Other Syndromes Requiring Lumbar Puncture in Emergency Department

In brief

Of all emergency room patients, persons presenting with encephalitis/meningitis syndrome of a potentially infectious nature are among those of greatest concern. Routine clinical and laboratory evaluation of such patients involves screening for known infectious disease agents, selection of which is nonstandardized. Progress in diagnostic technologies, especially molecular techniques based on genetic characteristics of potential pathogens, has greatly expanded the investigators capacity to evaluate specimens from patients for a much wider range of potential pathogens (bacterial, viral, fungal and parasitic agents). Use of Polymerase Chain Reaction (PCR) technology offers the possibility of identifying causative agents for the approximately 50% of all such presentations which go un-diagnosed. The investigators propose a study involving a collaboration between the EMERGEncy ID NET, a network of 10 geographically diverse university-affiliated urban emergency departments (coordinated by Olive View-UCLA Medical Center) and the Centers for Disease Control and Prevention (CDC), to use these new technologies to address this issue.

Key facts

Study ID
NCT02207647
Run by
Olive View-UCLA Education & Research Institute
People needed
1000
Starts
2014-04-01
Expected to finish
2021-12-01
Last updated by the study team
2022-04-20

Who can join

Age: 0 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

You may not qualify if…

Where it is running

Full record on ClinicalTrials.gov

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