Evaluating PCSK9 Binding antiBody Influence oN coGnitive HeAlth in High cardiovascUlar Risk Subjects

Completed · Phase 3 · Has a placebo group

Conditions studied: Dyslipidemia

In brief

This study evaluated change over time in neurocognitive testing in patients receiving statin therapy in combination with evolocumab (AMG 145), compared with patients receiving statin therapy in combination with placebo.

Key facts

Study ID

NCT02207634

Run by

Amgen

People needed

1974

Starts

2014-09-10

Expected to finish

2016-11-11

Last updated by the study team

2018-01-16

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Randomized into Study 20110118 (FOURIER; NCT01764633)

You may not qualify if…

• Current or known past diagnosis of dementia or mild cognitive impairment (MCI)

Where it is running

• Research Site — Huntsville, Alabama, United States
• Research Site — Mobile, Alabama, United States
• Research Site — Glendale, Arizona, United States
• Research Site — Phoenix, Arizona, United States
• Research Site — Alhambra, California, United States
• Research Site — Banning, California, United States
• Research Site — Harbor City, California, United States
• Research Site — Laguna Hills, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Oceanside, California, United States
• Research Site — Oxnard, California, United States
• Research Site — Palm Springs, California, United States
• Research Site — Roseville, California, United States
• Research Site — Sacramento, California, United States
• Research Site — San Pedro, California, United States
• Research Site — Tarzana, California, United States
• Research Site — Thousand Oaks, California, United States
• Research Site — Aurora, Colorado, United States
• Research Site — Colorado Springs, Colorado, United States
• Research Site — Denver, Colorado, United States
• Research Site — Bridgeport, Connecticut, United States
• Research Site — Boynton Beach, Florida, United States
• Research Site — Crystal River, Florida, United States
• Research Site — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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