Magnetic Resonance Imaging in Obstructive Sleep Apnea
Withdrawn before enrolling
Conditions studied: Obstructive Sleep Apnea
In brief
There is a fundamental gap in the investigators ability to design effective surgical treatment of obstructive sleep apnea (OSA) for the 30-40% of patients who cannot tolerate non-surgical treatment. OSA surgery outcomes vary widely, with the chances of a successful outcome ranging from 5% to 65% for individual or combination procedures. To predict - and thereby to improve - outcomes, the investigators must determine what predicts surgical success. This project will compare findings from two evaluations: drug-induced sleep endoscopy (DISE) and upper airway magnetic resonance imaging (MRI). DISE has demonstrated important benefits, but it has important limitations. Upper airway MRI is the most complete evaluation performed during wakefulness, making it conducive to broad application and less expensive than DISE, but there are no studies utilizing MRI as a surgical evaluation. The investigators propose a cross-sectional analysis of 40 adult subjects with moderate to severe OSA. In addition to history, physical examination, and polysomnogram (sleep study), all subjects will undergo DISE and MRI to characterize the pattern of obstruction. The investigators will examine the association between DISE and MRI, focusing on specific DISE findings that have been associated with surgical outcomes. The investigators multidisciplinary team has substantial expertise and experience in OSA investigation, DISE, and upper airway MRI.
Key facts
- Study ID
- NCT02207127
- Run by
- University of Southern California
- People needed
- 0
- Starts
- 2023-05-08
- Expected to finish
- 2023-05-08
- Last updated by the study team
- 2023-08-14
Who can join
Age: 21 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- age ≥ 21 years; moderate to severe OSA (AHI ≥15 events/hour)
- body mass index <40 kg/m2.
You may not qualify if…
- prior OSA surgery
- known neurologic, cardiac, pulmonary, renal, or hepatic disorders
- psychiatric problems except for treated depression or mild anxiety
- co-existing sleep disorder other than OSA
- other contraindication to DISE or MRI such as propofol allergy.
Where it is running
- Keck Hospital of USC — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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