Ixazomib as a Replacement for Carfilzomib and Bortezomib for Multiple Myeloma Patients
Completed · Phase 1/Phase 2
Conditions studied: Multiple Myeloma
In brief
The goal of this clinical research study is to evaluate the safety and effectiveness (good and bad effects) of ixazomib given as part of a combination therapy to treat subjects with relapsed (subjects whose disease came back) or refractory (subjects whose disease did not respond to past treatment) multiple myeloma. More specifically, the study is focused on subjects who were previously treated with bortezomib (Velcade®) or carfilzomib (Kyprolis®) and showed worsening of their myeloma while receiving either one of these drugs in combination therapy. This study is a Phase I/II. Ixazomib is an investigational drug, which means that ixazomib is currently being tested and is not yet approved by the United States Food and Drug Administration (FDA) for subjects with relapsed or refractory multiple myeloma. Ixazomib is a new study drug that belongs to the same class as bortezomib and carfilzomib; however, unlike bortezomib and carfilzomib, ixazomib is taken by mouth. Current studies investigating ixazomib are demonstrating that it is as safe as bortezomib and effective for the treatment of multiple myeloma both on its own and in combination with other multiple myeloma medications, such as lenalidomide and dexamethasone, or prednisone and melphalan.
Key facts
- Study ID
- NCT02206425
- Run by
- Oncotherapeutics
- People needed
- 45
- Starts
- 2014-09-01
- Expected to finish
- 2018-03-06
- Last updated by the study team
- 2023-10-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Comprehensive Blood and Cancer Center — Bakersfield, California, United States
- John Muir Health Clinical Research Center — Concord, California, United States
- California Cancer Associates for Research & Excellence (cCARE) — Encinitas, California, United States
- Robert A. Moss, MD, FACP, Inc — Fountain Valley, California, United States
- cCARE Fresno — Fresno, California, United States
- Comprehensive Cancer Center at Desert Regional Medical Center — Palm Springs, California, United States
- James Berenson, MD, Inc — West Hollywood, California, United States
- Cancer Specialists of North Florida — Fleming Island, Florida, United States
- Lewis Hall Singletary Oncology Center — Thomasville, Georgia, United States
- Oncology Specialists, SC — Niles, Illinois, United States
- Hattiesburg Clinic Hematology/Oncology — Hattiesburg, Mississippi, United States
- Vista Oncology — Olympia, Washington, United States
Full record on ClinicalTrials.gov
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