PET Assessment of Acute Lung Transplant Rejection
Stopped early
Conditions studied: Lung Disease
In brief
The purpose of this research study is to gain understanding of the basic responses of the lungs to inflammation and specifically if there may be a better way to detect graft inflammation using non-invasive methods as well as to determine the effectiveness of immunosuppressive treatment regimens in preventing acute rejection in lung transplant recipients.
Key facts
- Study ID
- NCT02204202
- Run by
- Washington University School of Medicine
- People needed
- 28
- Starts
- 2014-02-01
- Expected to finish
- 2017-02-04
- Last updated by the study team
- 2020-10-08
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Double-lung transplant recipient
- Scheduled for bronchoscopy with transbronchial biopsy
- Capable of lying still and supine with arms raised above the head within the PET/CT scanner for \~1.25 hours
- Capable of following instructions for breathing protocol during CT portion of PET/CT
- Able and willing to give informed consent
- BMI < 35
- Already scheduled to undergo bronchoscopy with bronchoalveolar lavage (BAL) for clinical reasons
- Willing to donate a portion of BAL and biopsy specimen for laboratory testing
You may not qualify if…
- Glucose level > 150 mg/dl at time of [18F]FDG PET scan (however, up to 160 mg/dl, with repeat testing showing level is stable or decreasing, is acceptable)
- Pregnancy (confirmed by qualitative urine human chorionic gonadotropin (hCG) pregnancy test)
- Lactation
- Presence of implanted electronic medical device
- Enrollment in another research study of an investigational drug
- Inability to lie flat with arms raised above the head for 1.5 hours for PET/CT scans or follow breathing protocol instructions for the CT portion of the PET/CT
Where it is running
- Washington University School of Medicine / Barnes-Jewish Hospital — St Louis, Missouri, United States
Full record on ClinicalTrials.gov
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