Follow-up Yttrium-90 Internal Pair Production PET/CT vs Brehmsstrahlung Imaging in Patients With Primary/Metastatic Liver Tumors

Completed · Not applicable

Conditions studied: Liver Cancer, Hepatic Tumors

In brief

This is a prospective non-blinded case series involving the acquisition of a pair production PET/CT as soon as possible after an already performed Y-90 Sirspheres treatment of hepatic malignancy. It will be performed in addition to the standard Brehmsstrahlung SPECT scan. The sequence of the two scans in each case (PET/CT vs SPECT) will be determined by availability of the scanners at the time. However, it is intended that both be acquired on the day of the Y-90 treatment. The length of subject participation will be one year. The measures used will be mostly qualitative in nature, and will include: * Correlation with expected vs. achieved tumor coverage by the treatment * Correlation between treatment distribution depicted by Brehmsstrahlung scans vs. the Internal Pair Production PET/CT scans, to. * Detection of non-target embolization, where applicable, and qualitative comparison between the two modalities as to the conspicuity of the abnormality Qualitative methods will be used by the analysis of the obtained PET/CT images and comparing them to the Brehmsstrahlung SPECT images as previously described.

Key facts

Study ID

NCT02202317

Run by

University of Miami

People needed

9

Starts

2013-04-01

Expected to finish

2016-10-01

Last updated by the study team

2017-12-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Recipient of Selective Internal Radiation Treatment within 5 days.
• Anticipated ability to remain still for up to 40 minutes

You may not qualify if…

• Anticipated Inability to lie still for up to 40 minutes
• Severe claustrophobia
• Significant cardiovascular instability, or instability of other medical/surgical conditions, such that it would be deemed unsafe or technically not feasible to obtain a PET/CT, as determined by the any member of the investigative team
• Failed deployment of the planned Y-90 treatment for any reason
• Duration of time longer than 5 days since administration of the Y-90 treatment
• Age <18
• Known pregnancy

Where it is running

• Jackson Health System — Miami, Florida, United States

Full record on ClinicalTrials.gov

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