Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes

Completed

Conditions studied: Familial Adenomatous Polyposis, Map Syndrome, Lynch Syndrome, Hnpcc, Colorectal Cancer

In brief

This is an observational, case-control study evaluating the quantitative level of Septin9 in plasma pre- and post-colectomy in hereditary colorectal cancer (CRC) syndrome patients (Familial Adenomatous Polyposis (FAP), Lynch syndrome (also known as HNPCC), and Multiple Adenomatous Polyposis (MAP, also known as MYK/MYH) cases) and genetically related FAP-family members as controls and references.

Key facts

Study ID

NCT02198092

Run by

University of Pennsylvania

People needed

24

Starts

2014-07-01

Expected to finish

2019-08-01

Last updated by the study team

2019-08-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Informed consent provided
• Age > or = to 18 years of age
• Patient group FAP
• Clinical diagnosis of familial adenomatous polyposis
• Patient group Lynch syndrome Clinical diagnosis of Lynch syndrome
• Patient group MAP
• Clinical diagnosis of MYH-associated polyposis and presence of more than 20 colon polyps
• Control group (FAP)
• Genetically related family member of patient
• Patients: Able and willing to attend routine follow-up as advised
• Controls, i.e. relatives of patients: Willingness to give blood at each routine follow-up as advised for the diseased relative

You may not qualify if…

• Known infection with Human Immunodeficiency Virus (HIV), Hepatitis B Virus (HBV), or Hepatitis C Virus (HCV)
• Current diagnosis of colorectal cancer
• Pregnancy

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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