Assessment of Cardiopulmonary Function in Duchenne Muscular Dystrophy

Completed

Conditions studied: Muscular Dystrophy, Duchenne

In brief

This study seeks to develop and validate non-invasive assessments of cardiac and respiratory muscles with magnetic resonance imaging (MRI) to better predict the natural disease progression of Duchenne muscular dystrophy (DMD) in affected individuals over time, as well as determine whether peripheral skeletal muscle dysfunction can predict cardiopulmonary dysfunction. The central hypothesis is that non-invasive MRI measures of the heart, muscle, and peripheral skeletal muscles can sensitively predict future cardiopulmonary decline.

Key facts

Study ID

NCT02195999

Run by

University of Florida

People needed

9

Starts

2013-12-01

Expected to finish

2019-03-06

Last updated by the study team

2019-07-08

Who can join

Age: 5 and older, up to 15. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male
• 5-15 years old at the time of enrollment
• Diagnosed with DMD (as defined by parent project)
• Written parental informed consent (and assent where appropriate) before any study procedures take place

You may not qualify if…

• Contraindication to an MRI examination
• Presence of a secondary condition that impacts muscle function or metabolism, that leads to developmental delay or impaired motor control, or that is not stable
• Participant is unable to comply with study requirements
• Congenital structural abnormality of the heart, repaired or unrepaired
• Clinically contraindicated participation

Where it is running

• Clinical and Translational Research Building — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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