Comparison of Nasal Steroids After FESS in CRSwNP

Completed · Not applicable

Conditions studied: Sinusitis, Nasal Polyps

In brief

The purpose of this study is to compare intranasal fluticasone spray with budesonide nasal saline rinses in both the upright and head forward positions in patients who have had functional endoscopic sinus surgery (FESS) for chronic rhinosinusitis with nasal polyposis (CRSwNP) and measure differences in Sinonasal Outcome Test-22 (SNOT-22) scores and Lund- Kennedy scores on rigid nasal endoscopy at time points 1 week, 3 weeks, 6 weeks, 2 months, 4 months, and 6 months post-op.

Key facts

Study ID

NCT02194062

Run by

Yale University

People needed

32

Starts

2015-01-01

Expected to finish

2015-08-01

Last updated by the study team

2018-02-08

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients who have had FESS for CRSwNP within the study period

You may not qualify if…

• Patients who are under the age of 18
• Concurrent oral corticosteroid use of the equivalent of greater than 10 mg of prednisone use per day
• The use of medications that accelerate the clearance of systemic cortisol (Dilantin, rifampin, amphetamines, and lithium)
• The use of medications that inhibit the clearance of systemic cortisol (ketoconazole, amphotericin B, bupropion, fluoroquinolones)
• Known hypersensitivity to corticosteroids
• A personal history of Wegener's Granulomatosis or other autoimmune disease with nasal manifestations

Where it is running

• Yale Physicians Bldg — New Haven, Connecticut, United States
• Yale ENT Stratford — Stratford, Connecticut, United States

Full record on ClinicalTrials.gov

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