Dietary Methionine and Cysteine Restriction in Healthy Adults

Completed · Not applicable

Conditions studied: Healthy

In brief

Studies in laboratory models indicate that dietary methionine restriction (MR) enhances longevity and produces short- and long-term metabolic changes that are consistent with a healthy lifespan. The present study was designed to establish levels of dietary methionine or methionine and cysteine that induce physiological changes in healthy adults like those observed in rodent studies .

Key facts

Study ID

NCT02192437

Run by

Milton S. Hershey Medical Center

People needed

20

Starts

2014-07-16

Expected to finish

2017-07-01

Last updated by the study team

2020-09-07

Who can join

Age: 24 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy English speaking male and female volunteers
• May or may not be students
• Age range 24-65 years
• Subjects will need to be of normal weight or moderately overweight (BMI 18.5-35 kg/m2)
• Subjects will be non-smokers

You may not qualify if…

• No use of medications known to impact the biomarkers of interest
• Pregnancy and lactating women
• Persons with documented diabetes
• No use of high dose dietary antioxidant supplements or fish oil/flax seed oil for n-acetylcysteine for at least 1 month prior to the study
• Use of tobacco products over the past 6 months
• Unstable weight
• Individuals with allergies to eggs, wheat, nuts, soy and latex
• Individuals with phenylketonuria (PKU)

Where it is running

• Penn State University — State College, Pennsylvania, United States

Full record on ClinicalTrials.gov

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