A Study of LY2951742 in Participants With Mild to Moderate Osteoarthritis Knee Pain

Stopped early · Phase 2 · Has a placebo group

Conditions studied: Osteoarthritis, Knee

In brief

The main purpose of this study is to test if LY2951742 relieves mild to moderate knee pain. The study drugs will be given as an injection under the skin and as an oral capsule. The study will last about 28 weeks for each participant.

Key facts

Study ID

NCT02192190

Run by

Eli Lilly and Company

People needed

268

Starts

2014-07-01

Expected to finish

2015-06-01

Last updated by the study team

2019-09-10

Who can join

Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology (ACR) criteria and confirmed with X-rays and ACR functional class of I to III
• Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs (NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at least 20 days in the past month
• Willing to stop all analgesics for OA pain during the study
• Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100 Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm following washout of current Osteoarthritis pain medications at screening

You may not qualify if…

• Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs
• Arthritis of the knee from other causes
• Uncontrolled hypertension
• Have OA pain that requires treatment with potent opioids, systemic corticosteroids, intra-articular injections, duloxetine, or venlafaxine
• Moderate to severe renal impairment
• Pregnant or lactating

Where it is running

• Achieve Clinical Research, LLC — Birmingham, Alabama, United States
• Dream Team Clinical Research — Anaheim, California, United States
• Artemis Institute for Clinical Research — San Diego, California, United States
• Empire Clinical Research — Upland, California, United States
• Diablo Clinical Research — Walnut Creek, California, United States
• iM Research — West Covina, California, United States
• Horizons Clinical Research Center — Denver, Colorado, United States
• Avail Clinical Research LLC — DeLand, Florida, United States
• AGA Clinical Trials — Hialeah, Florida, United States
• Palm Springs Research Institute — Hialeah, Florida, United States
• Community Research Foundation Inc — Miami, Florida, United States
• Research Institute of South Florida, Inc. — Miami, Florida, United States
• M&M Medical Center — Miami, Florida, United States
• Renstar Medical Research — Ocala, Florida, United States
• Compass Research — Orlando, Florida, United States
• United Osteoporosis Center — Gainesville, Georgia, United States
• Drug Studies America — Marietta, Georgia, United States
• Medex Healthcare Research, Inc. — Chicago, Illinois, United States
• Buynak Clinical Research, P.C. — Valparaiso, Indiana, United States
• Beacon Clinical Research, LLC — Brockton, Massachusetts, United States
• ActivMed Practices & Research, Inc — Methuen, Massachusetts, United States
• The Center for Clinical Trials, Inc. — Biloxi, Mississippi, United States
• Arthritis, Rheumatic & Back Disease Associates — Voorhees Township, New Jersey, United States
• New Mexico Clinical Research & Osteoporosis Center — Albuquerque, New Mexico, United States
• Drug Trials of America — Hartsdale, New York, United States

Full record on ClinicalTrials.gov

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