YouScript IMPACT Registry
Completed
Conditions studied: Adverse Drug Events, Adverse Drug Reactions, Drug Interaction Potentiation, Drug Metabolism, Poor, CYP2D6-RELATED, Drug Metabolism, Poor, CYP2C19-RELATED, Cytochrome P450 Enzyme Deficiency, Cytochrome P450 CYP2D6 Enzyme Deficiency, Cytochrome P450 CYP2C9 Enzyme Deficiency, Cytochrome P450 CYP2C19 Enzyme Deficiency, Cytochrome P450 CYP3A Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2C9 Variant, Poor Metabolizer Due to Cytochrome P450 CYP2C19 Variant, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
In brief
This multicenter observational study aims to investigate the benefits of providing pharmacogenetic testing with the YouScript Personalized Prescribing System which includes a clinical decision support tool and individualized pharmacist recommendations to elderly polypharmacy patients who are most at risk of adverse drug events. The YouScript system is unique in identifying drug-gene, and drug-drug-gene interactions that are missed by existing systems, and represent over 35% of significant interaction warnings. Data analysis will assess the impact of recommendations for medication changes on clinical decision making, patient outcomes, and healthcare resource utilization to determine which medications, specialties, or patient segments derive the greatest benefit from this intervention. Data gathered from patients enrolled in this study will be compared to patients matched on key characteristics from Inovalon's MORE2 healthcare database.
Key facts
- Study ID
- NCT02191358
- Run by
- Genelex Corporation
- People needed
- 800
- Starts
- 2014-10-01
- Expected to finish
- 2015-08-01
- Last updated by the study team
- 2017-03-01
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Dr. Michael Dao — Garden Grove, California, United States
- Kaiser Permanente Colorado — Denver, Colorado, United States
- Gill Heart Institute — Lexington, Kentucky, United States
- IRC Clinics — Towson, Maryland, United States
- Internal Medicine & Cardiology Associates — Fall River, Massachusetts, United States
- Prima CARE — Fall River, Massachusetts, United States
- Carilion Clinic — Christiansburg, Virginia, United States
Full record on ClinicalTrials.gov
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