Endogenous Opioid Mechanisms for Rejection Sensitivity

Completed

Conditions studied: Rejection Sensitivity

In brief

This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders. This project will use positron emission tomography to measure the brain's opioid response to social rejection and acceptance in a nonclinical population with varying levels of rejection sensitivity. The results will provide the first major step towards understanding a neurotransmitter mechanism for rejection sensitivity, allowing for further investigation into predicting and treating its associated disorders.

Key facts

Study ID

NCT02189785

Run by

Stony Brook University

People needed

114

Starts

2016-08-01

Expected to finish

2019-06-06

Last updated by the study team

2020-10-22

Who can join

Age: 18 and older, up to 25. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men and women age 18-25 (inclusive)
• Right-handed
• Native English speaker
• Not currently in a romantic relationship
• Willing and able to participate in a PET scan

You may not qualify if…

• Not on hormonal birth control
• Not pregnant
• Consume less than 5 cigarettes per week and less than 14 alcoholic drinks per week, on average
• No use of recreational or street drugs in the past two years (e.g. marijuana)
• Willing to abstain from alcohol and/or tobacco for 48 hours
• No major untreated medical problems
• Never diagnosed with a psychiatric or neurological disorder
• Potential problems with having an MRI scan (claustrophobia, metal objects, etc.)

Where it is running

• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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