Radiotherapy of Motor Deficits From Metastatic Epidural Spinal Cord Compression

Completed · Not applicable

Conditions studied: Metastatic Epidural Spinal Cord Compression

In brief

The primary aim of this randomized multi-center trial is to investigate the efficacy of the radiotherapy regimens 5 x 4 Gy and 10 x 3 Gy with respect to the effect on motor function in patients with metastatic epidural spinal cord compression.

Key facts

Study ID

NCT02189473

Run by

Prof. Dirk Rades, MD

People needed

203

Starts

2010-07-01

Expected to finish

2015-07-01

Last updated by the study team

2020-03-05

Who can join

Age: 18 and older, up to 89. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Motor deficits of the lower extremities resulting from metastatic epidural spinal cord compression, which have persisted for no longer than 30 days
• Confirmation of diagnosis by magnetic resonance imaging (spinal computed tomography allowed)
• Relatively poor survival prognosis (defined as ≤35 points on the survival score published in Cancer 2008)
• Written informed consent

You may not qualify if…

• Prior radiotherapy or surgery of the spinal areas affected by MESCC
• History of symptomatic brain tumor or symptomatic brain metastases
• Metastases of the cervical spine only
• Other severe neurological disorders
• Pregnancy, Lactation
• Indication for decompressive surgery + stabilization of the affected spinal areas

Where it is running

• Mayo Clinic — Scottsdale, Arizona, United States
• Oberschwabenklinik Ravensburg — Ravensburg, Baden-Wutemberg, Germany
• Klinikum Bayreuth — Bayreuth, Bavaria, Germany
• University of Regensburg — Regensburg, Bavaria, Germany
• University of Würzburg — Würzburg, Bavaria, Germany
• Ruhr University — Bochum, North Rhine-Westphalia, Germany
• Radiotherapy Practice Dresden-Friedrichstadt — Dresden, Saxony, Germany
• University of Lübeck — Lübeck, Schleswig-Holstein, Germany
• Charite Berlin — Berlin, Germany
• Center of Radiotherapy and Radiation Oncology — Bremen, Germany
• Institute of Oncology, Vilnius University — Vilnius, Lithuania
• Saad Specialist Hospital — Khobar, Saudi Arabia
• Institute of Oncology — Ljubljana, Slovenia
• Consorcio Hospitalario Provencial de Castellon — Valencia, Castellon, Spain
• Cruces University Hospital — Barakaldo, Vizcaya (Basque Country), Spain

Full record on ClinicalTrials.gov

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