Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery

Completed

Conditions studied: Cytoreductive Surgery

In brief

Serum procalcitonin levels will be considerably higher, for a longer period of time, in patients who develop sepsis compared to patients with SIRS or those who have an uncomplicated post-surgical recovery. Monitoring of serum procalcitonin trends will allow for an earlier diagnosis of, and initiation of treatment for, sepsis compared to current standard ICU methods.

Key facts

Study ID

NCT02189434

Run by

Eastern Regional Medical Center

People needed

20

Starts

2014-06-01

Expected to finish

2016-04-01

Last updated by the study team

2017-07-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Female or male person ≥ 18 years of age
• Biopsy proven carcinoma
• Scheduled for cytoreductive surgery, with or without HIPEC
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) = 0, 1, or 2
• Able to give informed consent for protocol participation

You may not qualify if…

• Participants are not able to understand or provide written informed consent
• Pre-operative anti-inflammatory medication use within 72 hours of their baseline blood draw
• Pre-operative infection treatment with corticosteroids within 72 hours of their baseline blood draw
• Immunosuppressive illness other than neoplasm
• Pregnant or lactating female

Where it is running

• Eastern Regional Medical Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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