Effects of Electronic Cigarettes on Lung Biology

Stopped early · Not applicable · Has a placebo group

Conditions studied: Lung Disease, Lung Disorder

In brief

E-cigarettes are an increasingly popular alternate nicotine delivery system, but nothing is known about the effects of electronic cigarettes on the lungs. We hypothesize that e-cigarettes disorder airway epithelial and alveolar macrophages biology. Our goal is not to carry out a large epidemiologic study of electronic cigarette users to study lung function and other possible abnormal clinical phenotypes, but rather to focus on whether electronic cigarette smoke disorders the biology of the lung cells first exposed to the electronic cigarette smoke, a parameter that is the precursor of abnormalities in lung function and which is far more sensitive than lung function.

Key facts

Study ID

NCT02188511

Run by

Weill Medical College of Cornell University

People needed

13

Starts

2014-01-01

Expected to finish

2018-07-01

Last updated by the study team

2020-07-24

Who can join

Age: 21 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females, age 21 or older
• Must be capable of providing informed consent
• Self-reported never-smokers, with current smoking status validated by the absence of nicotine metabolites in urine (nicotine <2 ng/ml and cotinine <5 ng/ml)
• Normal physical examination
• Good overall health without history of chronic lung disease, including asthma, and without recurrent or recent (within 3 months) acute pulmonary disease
• Normal routine laboratory evaluation, including general hematologic studies, general serologic/immunologic studies, general biochemical analyses, and urine analysis
• Not taking any medications relevant to lung disease or having an effect on the airway epithelium
• Negative HIV serology
• Normal chest X-ray (PA and lateral)
• Normal electrocardiogram (sinus bradycardia, premature atrial contractions are permissible)
• Females - not pregnant
• No history of allergies to medications to be used in the bronchoscopy procedure
• Willingness to participate in the study

You may not qualify if…

• Unable to meet the inclusion criteria
• Current active infection or acute illness of any kind
• Evidence of malignancy within the past 5 years
• Current alcohol or drug abuse
• Pregnancy

Where it is running

• Weill Cornell Medical College — New York, New York, United States

Full record on ClinicalTrials.gov

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