Transplant-Related Mortality in Patients Undergoing a Peripheral Blood Stem Cell Transplantation or an Umbilical Cord Blood Transplantation

Completed

Conditions studied: Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome

In brief

Study CR-AIR-006 is a part of the ATIR clinical development plan and will provide control data for patients treated with ATIR in clinical studies (e.g. study CR-AIR-007).

Key facts

Study ID

NCT02188290

Run by

Kiadis Pharma

People needed

178

Starts

2014-09-01

Expected to finish

2015-06-01

Last updated by the study team

2015-10-06

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Any of the following hematologic malignancies:
• Acute myeloid leukemia (AML) in remission at the time of the transplantation
• Acute lymphoblastic leukemia (ALL) in remission at the time of the transplantation
• Myelodysplastic syndrome (MDS)
• Patient received any of the following transplantations:
• Allogeneic T-cell depleted HSCT without ATIR administration from a haploidentical donor between 1 January 2006 and 30 June 2013 (HAPLO group)
• Allogeneic HSCT from a fully matched or 1-locus mismatched unrelated donor between 1 January 2010 and 31 December 2012 (MUD/MMUD groups)
• Double umbilical cord blood transplantation between 1 January 2010 and 31 December 2012 with no more than 2 human leukocyte antigen (HLA)-mismatches at HLA-A, B, and/or -DR between each of the units and the recipient (UCB group)
• Male or female, age ≥ 18, ≤ 65 years.

You may not qualify if…

• Allogeneic stem cell transplantation prior to the transplantation qualifying for the study.

Where it is running

• Ohio State University Comprehensive Cancer Center — Columbus, Ohio, United States
• Algemeen Ziekenhuis Sint-Jan — Bruges, Belgium
• Institut Jules Bordet — Brussels, Belgium
• Universitair Ziekenhuis Gasthuisberg — Leuven, Belgium
• Hamilton Niagara Regional Haemophilia Centre — Hamilton, Ontario, Canada
• Maisonneuve-Rosemont Hospital — Montreal, Quebec, Canada
• Universitätsklinikum Würzburg — Würzburg, Germany
• Academisch Ziekenhuis Maastricht — Maastricht, Netherlands
• Hammersmith Hospital — London, United Kingdom

Full record on ClinicalTrials.gov

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