Diuretic Comparison Project
Completed · Phase 3
Conditions studied: Hypertension
In brief
The Diuretic Comparison Project aimed to evaluate whether chlorthalidone, as compared with hydrochlorothiazide, would reduce the risk of major nonfatal cardiovascular disease outcomes and non-cancer-related deaths in older patients with hypertension who were receiving hydrochlorothiazide at baseline. The investigators incorporated the pragmatic methods used by the Department of Veterans Affairs (VA) Healthcare System to provide a real-world assessment of the effectiveness of chlorthalidone as compared with hydrochlorothiazide in routine clinical care.
Key facts
- Study ID
- NCT02185417
- Run by
- VA Office of Research and Development
- People needed
- 20723
- Starts
- 2016-06-15
- Expected to finish
- 2022-12-29
- Last updated by the study team
- 2024-05-22
Who can join
Age: 65 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- over age 65 years
- receiving hydrochlorothiazide from the VA pharmacy at a daily dose of 25 or 50 mg
- most recent SBP ≥120 mm Hg and no records of SBP <120 mm Hg in the past 90 days
You may not qualify if…
- impaired decision-making capacity rendering the patient unable to provide informed consent (i.e., if there is any question during the nurse's EHR chart review that the individual does not have the ability to make an autonomous decision or the PCP declines permission to randomize)
- death expected within 6 months (inferred by PCP permission to randomize)
- blood potassium level <3.1 or 3.5 (if taking digoxin) meq/L in the past 90 days
- blood sodium level <130 meq/L in the past 90 days
- enrolled in Medicare Part C (This exclusion only applied if there might be insufficient EHR data available to the study team)
Where it is running
- Alaska VA Healthcare System, Anchorage, AK — Anchorage, Alaska, United States
- Veterans Health Care System of the Ozarks, Fayetteville, AR — Fayetteville, Arkansas, United States
- Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR — Little Rock, Arkansas, United States
- VA Central California Health Care System, Fresno, CA — Fresno, California, United States
- VA Long Beach Healthcare System, Long Beach, CA — Long Beach, California, United States
- VA Palo Alto Health Care System, Palo Alto, CA — Palo Alto, California, United States
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA — West Los Angeles, California, United States
- Rocky Mountain Regional VA Medical Center, Aurora, CO — Aurora, Colorado, United States
- Grand Junction VA Medical Center, Grand Junction, CO — Grand Junction, Colorado, United States
- VA Connecticut Healthcare System West Haven Campus, West Haven, CT — West Haven, Connecticut, United States
- Wilmington VA Medical Center, Wilmington, DE — Wilmington, Delaware, United States
- Washington DC VA Medical Center, Washington, DC — Washington D.C., District of Columbia, United States
- Bay Pines VA Healthcare System, Pay Pines, FL — Bay Pines, Florida, United States
- North Florida/South Georgia Veterans Health System, Gainesville, FL — Gainesville, Florida, United States
- VA Pacific Islands Health Care System, Honolulu, HI — Honolulu, Hawaii, United States
- Boise VA Medical Center, Boise, ID — Boise, Idaho, United States
- VA Illiana Health Care System, Danville, IL — Danville, Illinois, United States
- Edward Hines Jr. VA Hospital, Hines, IL — Hines, Illinois, United States
- Captain James A. Lovell Federal Health Care Center, North Chicago, IL — North Chicago, Illinois, United States
- Richard L. Roudebush VA Medical Center, Indianapolis, IN — Indianapolis, Indiana, United States
- VA Central Iowa Health Care System, Des Moines, IA — Des Moines, Iowa, United States
- Iowa City VA Health Care System, Iowa City, IA — Iowa City, Iowa, United States
- Maine VA Medical Center, Augusta, ME — Togus, Maine, United States
- Rehabilitation R&D Service, Baltimore, MD — Baltimore, Maryland, United States
- Birmingham VA Medical Center, Birmingham, AL — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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