Integrative-omics of the Disordered COPD Small Airway Epithelium
Completed
Conditions studied: Smoking, COPD
In brief
We aim to use an integrated network systems approach to analyze certain existing small airway epithelium (SAE) omic data sets at the genetic, epigenetic (methylation), gene expression, microRNA and metabolomic levels, to develop an initial model of network connectivities and key network pressure points relevant to SAE biology in health and disease.
Key facts
- Study ID
- NCT02183818
- Run by
- Weill Medical College of Cornell University
- People needed
- 42
- Starts
- 2015-04-06
- Expected to finish
- 2020-10-15
- Last updated by the study team
- 2021-05-28
Who can join
Age: 18 and older, up to 100. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Must be enrolled into IRB approved protocol #1204012331(all inclusion criteria from protocol #1204012331 thus applies to this protocol)
- Self-reported never-smokers, with current smoking status validated by the absence of nicotine metabolites in urine (nicotine less than 2 ng/ml and cotinine less than 5 ng/ml)
- Negative HIV serology
- Smokers with COPD (n=50)
- Inclusion criteria
- Must be enrolled into IRB approved protocol #1204012331(all inclusion criteria from protocol #1204012331 thus applies to this protocol)
- Self-reported current daily smokers with greater than or equal to 10 pack-yr, validated by any of the following: urine nicotine greater than 30 ng/ml or urine cotinine greater than 50 ng/ml
- Meeting GOLD stages I-III criteria for chronic obstructive lung disease (COPD) based on postbronchodilator spirometry
- Taking any or no pulmonary-related medication, including beta-agonists, anticholinergics, or inhaled corticosteroids
- Negative HIV serology
- Healthy nonsmokers (n=50)
You may not qualify if…
- Unable to meet the inclusion criteria (all exclusion criteria from protocol #1204012331 applies to this protocol)
- Evidence of malignancy within the past 5 years
- Smokers with COPD (n=50)
- Exclusion criteria
- Unable to meet the inclusion criteria (all exclusion criteria from protocol #1204012331 applies to this protocol)
- Individuals in whom participation in the study would compromise the normal care and expected progression of their disease
- Evidence of malignancy within the past 5 years
Where it is running
- Weill Cornell Medical College — New York, New York, United States
Full record on ClinicalTrials.gov
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