Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease

Completed · Phase 1/Phase 2

Conditions studied: Cough, Parkinson's Disease

In brief

The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs. The investigators want to compare the movement of the chest wall and the lungs during voluntary and reflex cough. The long-term goal of this research is to develop treatments for people with cough dysfunction. Cough dysfunction increases the risk for respiratory infections such as pneumonia. The results from this study will provide information to help researchers understand the difference between reflex and voluntary cough more fully.

Key facts

Study ID

NCT02183519

Run by

University of Florida

People needed

44

Starts

2014-10-01

Expected to finish

2015-08-01

Last updated by the study team

2017-03-24

Who can join

Age: 55 and older, up to 85. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 55-85 years
• Ability to provide informed consent
• For participants with Parkinson's disease (PD):
• Diagnosis of PD (Hoehn \& Yahr stages II-IV) by a University of Florida Movement Disorders fellowship trained neurologist having completed a clinical assessment of each participant's PD severity and arriving at the diagnosis of PD by applying strict United Kingdom brain bank criteria.

You may not qualify if…

• Participants with PD:
• History of neurological disorders other than PD (e.g. multiple sclerosis, stroke, brain tumor, etc)
• Healthy older adults:
• History of neurological disease including PD
• History of head and neck cancer
• History of breathing disorders or disease (i.e. chronic obstructive pulmonary disease, asthma)
• History of smoking for more than 5 years at any one time (as this reduces the sensitivity to capsaicin)
• History of chest infection the last 5 weeks
• Failure of a screening test of pulmonary function (e.g. forced expiratory volume in one second/forced vital capacity<75%)
• Difficulty complying due to neuropsychological dysfunction (i.e. severe depression)

Where it is running

• Center for Movement Disorders and Neurorestoration — Gainesville, Florida, United States
• Dauer Hall, University of Florida — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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