Emergency Ketamine Treatment of Suicidal Ideation

Status unconfirmed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Depression, Suicidal Ideation, Suicidal Impulses

In brief

The objective of the current program of research will be to test whether intranasal ketamine treatment is more effective than placebo in reducing suicidal ideation in suicidal patients presenting for acute treatment in emergency department settings. Secondary objectives will test the effect of genotypic differences in the mu opioid receptor on efficacy of ketamine and the correlation of speech patterns and facial movement patterns with subjective reductions in suicidal ideation after ketamine treatment.

Key facts

Study ID

NCT02183272

Run by

University of Cincinnati

People needed

60

Starts

2016-08-01

Expected to finish

2018-07-01

Last updated by the study team

2016-08-05

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males and females
• Ages 18-65
• All races and ethnicities
• Willing and able to provide informed consent
• A cutoff score of >3 on the Beck Scale for Suicidal Ideation
• >2 on the Columbia Scale for Suicide Severity Rating

You may not qualify if…

• Pregnancy or lactation; women of reproductive potential must have a negative urine pregnancy test
• Post-partum state (within 2 months of delivery)
• Homicide risk as determined by clinical interview
• Any of the following Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) diagnoses:
• Any current primary psychotic disorder
• Acute intoxication or withdrawal from alcohol or any other substance of abuse, as determined by clinical interview and urine drug screen except opioids
• use of any hallucinogen (except cannabis), in the last month
• Any dissociative disorder
• Pervasive developmental disorder
• Cognitive disorder
• Cluster A personality disorder
• Anorexia nervosa.
• Treatment with any medication known to affect the N-methyl-D-aspartate (NMDA) receptor system (e.g., lamotrigine, acamprosate, memantine, riluzole, or lithium)
• Any known hypersensitivity or serious adverse effect with ketamine
• Any clinically-significant medication or condition that would preclude the use of ketamine

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.