S. Aureus Screening and Decolonization

Completed · Phase 4

Conditions studied: Wound Infection Due to Staphylococcus Aureus, MRSA Infection of Postoperative Wound

In brief

Staphylococcus aureus (SA) healthcare-associated infections (HAI) cause significant morbidity and mortality. SA causes 15% of all HAI and 30% of surgical site infections (SSIs). Each year over 40 million Americans undergo operations, 1-10% of whom will acquire SSIs. Such infections double the length of hospitalization and risk of dying, and increase U.S. health care costs by $5-10 billion/year. We need effective interventions to prevent SSIs caused by either methicillin-susceptible (MSSA) or methicillin-resistant (MRSA) strains. Nasal carriers of SA (25-30% of adults) have a 2-14 times greater risk than non-carriers of acquiring an SA SSI. A potential prevention approach is routine pre-operative screening of patients, followed by decolonization of identified SA carriers.

Key facts

Study ID

NCT02182115

Run by

University of Minnesota

People needed

110

Starts

2014-07-01

Expected to finish

2016-08-01

Last updated by the study team

2019-11-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All patient who are 18 years and older, able to give informed consent and willing to complete the study decolonization protocol.
• Surgery must be scheduled 2 weeks in the future to allow completion of the study protocol prior to the scheduled operation.
• Patients will be admitted from home the day of the surgery or have the surgery done on an outpatient basis.

You may not qualify if…

• Currently on antibiotic therapy, allergy to mupirocin or CHG.

Where it is running

• University of Minnesota Medical Center — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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