Addition of Excimer Laser to Treatment With Acitretin Tablets for Psoriasis of the Palms and Soles
Stopped early · Phase 4
Conditions studied: Psoriasis, Skin or Nails
In brief
Psoriasis is a common skin disease that can affect 1-3% of the population. For more severe psoriasis, oral medication such as acitretin is sometimes given. While acitretin may be sufficient for treatment of some patients, psoriasis of the palms and soles is particularly challenging to treat, and may not respond to acitretin alone. In this study, the focus is on patients who have psoriasis of the palms and soles, and are currently taking acitretin. The aim is to initially recruit 10 patients and offer them treatment with a laser, the excimer laser, to one palm and one sole. Patients will receive laser treatment twice weekly for a total of 8 weeks, while also taking their acitretin tablet. If the side treated with the excimer laser shows greater improvement compared to the other side, the second part of the study will be conducted. In this second part, another 15 patients will be included. These patients will receive twice weekly treatments with the excimer laser to one both palms and/or soles, for a total of 8 weeks. The aim is to prove that the addition of excimer laser to treatment with acitretin will lead to greater improvement of psoriasis on palms and soles.
Key facts
- Study ID
- NCT02181790
- Run by
- Icahn School of Medicine at Mount Sinai
- People needed
- 2
- Starts
- 2014-06-01
- Expected to finish
- 2014-12-01
- Last updated by the study team
- 2021-03-10
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female subject at least 18 years of age
- Diagnosis of psoriasis, with palmoplantar involvement
- Initiated on oral acitretin for treatment of their psoriasis by their physician
You may not qualify if…
- Subjects less than 18 years old
- Subjects with any skin disease, disease state, or physical condition that would impair evaluation of the skin
- Additional systemic therapy for psoriasis in last 4 weeks
- Additional topical or photo-therapy in last 2 weeks
- Usage of any additional therapy except for emollients and keratolytic agents (5% salicylic acid ointment or 30% urea cream)
- Pre-existent or current cutaneous malignancy affecting the palms and/or soles
- History of photosensitive disorders
- Ingestion of drugs reported to cause photosensitivity reactions
- Presence of erythroderma or generalized pustular psoriasis
- Concomitant use of sunlamps
Where it is running
- Icahn School of Medicine at Mount Sinai — New York, New York, United States
Full record on ClinicalTrials.gov
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