Changes in Intrahepatic Lipids With Exercise
Completed · Not applicable
Conditions studied: Obese
In brief
Individuals with obesity and particular type 2 diabetes have abnormally high levels of fat in liver cells and are at increased risk for cardiovascular and liver-related mortality. Prior research has shown that caloric restriction, exercise, and behavior modification can help lower hepatic fat levels in these individuals. Additional research has also shown that exercise independent of weight loss can reduce hepatic fat content in obese humans. The current exercise guidelines do not specify what type or what intensity of exercise is required to induce such reductions in hepatic fat. Thus, the purpose for doing this study is to determine if there are differential effects on liver fat with 4 wk of high intensity intermittent exercise compared with continuous moderate exercise in obese individuals.
Key facts
- Study ID
- NCT02181270
- Run by
- University of Missouri-Columbia
- People needed
- 57
- Starts
- 2013-10-01
- Expected to finish
- 2017-06-01
- Last updated by the study team
- 2018-01-23
Who can join
Age: 21 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Overweight or obese with a body mass index between 30-45 kg/m2.
- No known cardiovascular, kidney, or liver disease.
- No extreme hypertension (>160 mm Hg systolic and/or > 100 mm Hg diastolic).
- Not being treated with exogenous insulin.
- No history of surgery for weight loss and weight stable for prior 3 months (weight change < 3 kg).
- Non-exerciser (< 20 minutes of exercise 2 days per week).
- Between 21-60 yr of age
You may not qualify if…
- History of alcohol use (> 20 g/day for males and > 10 g/day for females)
- Kidney or liver disease.
- Extreme hypertension >160 mm Hg systolic and/or > 100 mm Hg diastolic.
- Waist measurement greater than 60"
- Magnetic Resonance Spectroscopy scan with less than 5% of liver fat
- A history of surgery for weight loss.
- Exerciser (>20 minutes of exercise at least 2 days per week)
- Pregnant or lactating
- <21 or >60 yr of age
Where it is running
- University of Missouri — Columbia, Missouri, United States
Full record on ClinicalTrials.gov
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