Assessment of Cerebral Microvascular Circulation
Withdrawn before enrolling · Not applicable
Conditions studied: Cerebral Microvascular Circulation
In brief
One of the fundamental goals of anesthesia care is to optimize tissue perfusion and oxygenation, especially in critically ill patients. The standard monitors such as blood pressure, heart rate and pulse oximetry do not directly reflect tissue information and can be misleading sometimes. Coherent hemodynamics spectroscopy (CHS) based on cerebral oximetry is proposed as a continuous and non-invasive tool assessing cerebral microvascular hemodynamics. The investigators propose this study to explore the validity of CHS via comparison with transcranial Doppler measurement in anesthetized surgical patients. The hypotheses are: 1) CHS can effectively measure cerebral microvascular hemodynamic changes associated with mechanical ventilation adjustment during anesthesia. 2) CHS can assess functional status of cerebral autoregulation that is altered by hypercapnia and inhalational anesthetic agent.
Key facts
- Study ID
- NCT02179840
- Run by
- University of California, San Francisco
- People needed
- 0
- Starts
- 2015-03-01
- Expected to finish
- 2016-03-01
- Last updated by the study team
- 2019-01-08
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patients are 18 years of age or older
- Relative healthy (ASA I-II)
- Scheduled for elective intra-abdominal surgeries including colorectal, urological and gynecological procedures under general anesthesia with placements of endotracheal tube and radial arterial catheter.
- Paralysis is required for surgery
- A total of 30 patients will be recruited. These 30 patients are randomly divided into 2 groups based on the technique of anesthesia maintenance during surgery. The anesthesia in one group (n=15) is maintained using inhalational agent. The anesthesia in the other group (n=15) is maintained using intravenous agents.
You may not qualify if…
- Patients <18 years of age
- ASA physical status ≥III
- Emergent or urgent surgery
- Laparoscopic surgery
- History of pulmonary diseases including COPD
- Asthma
- Restrictive lung disease, etc.
- History of cardiac diseases including symptomatic coronary artery disease, heart failure, arrhythmia, moderate to severe valvular abnormalities, and cardiomyopathies
- History of neurological diseases including carotid artery disease, stroke or TIA, etc.
Where it is running
- UCSF — San Francisco, California, United States
Full record on ClinicalTrials.gov
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