Dual Energy CT for Ischemia Determination Compared to "Gold Standard" Non-Invasive and Invasive Techniques
Completed
Conditions studied: Ischemia
In brief
The purpose of this study is determine the diagnostic performance of dual energy computed tomography perfusion for non-invasive assessment of the hemodynamic significance of coronary stenosis, as compared to a direct measurement of fraction flow reserve during cardiac catheterization as a reference standard. The overall objective of the present study is to determine the diagnostic performance of dual energy computed tomography perfusion for non-invasive assessment of the hemodynamic significance of coronary stenosis, as compared to direct measurement of fraction flow reserve during cardiac catheterization as a reference standard.
Key facts
- Study ID
- NCT02178904
- Run by
- Weill Medical College of Cornell University
- People needed
- 156
- Starts
- 2014-03-01
- Expected to finish
- 2018-01-10
- Last updated by the study team
- 2019-10-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age ≥ 18 years
- Patients provide written informed consent
- Patients scheduled to undergo clinically-indicated non-emergent invasive coronary angiography
- suspected coronary artery disease
You may not qualify if…
- Suspicion of acute coronary syndrome (acute myocardial infarction and unstable angina)
- Recent prior myocardial infarction within 40 days of ICA
- Known complex congenital heart disease
- Significant arrhythmia or tachycardia
- Impaired chronic renal function (serum creatinine > 1.5 mg/dl or GFR < 30 ml/min)
- Patients with known anaphylactic allergy to iodinated contrast
- Pregnancy or unknown pregnancy status
- Contraindication to adenosine, including 2nd or 3rd degree heart block; sick sinus syndrome; long QT syndrome; severe hypotension, severe asthma, severe COPD or bronchodilator-dependent COPD
- Patient requires an emergent procedure
- Evidence of ongoing or active clinical instability, including acute chest pain (sudden onset), cardiogenic shock, unstable blood pressure with systolic blood pressure <90 mmHg, and severe congestive heart failure (NYHA III or IV) or acute pulmonary edema
Where it is running
- Midwest Heart and Vascular Specialists — Overland Park, Kansas, United States
- Weill Cornell Medical College — New York, New York, United States
- Wexner Medical Center, The Ohio State University Medical Center — Columbus, Ohio, United States
- Medical University of South Carolina — Charleston, South Carolina, United States
- University of Washington — Seattle, Washington, United States
Full record on ClinicalTrials.gov
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