Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease

Completed · Phase 2 · Has a placebo group

Conditions studied: Diabetic Kidney Disease

In brief

The primary objective of this study is to determine the effect of selonsertib (formerly GS-4997) on estimated glomerular filtration rate (eGFR) decline in participants with diabetic kidney disease (DKD). Participants will be randomized with a 1:1:1:1 allocation to receive 1 of 3 doses of selonsertib (2 mg, 6 mg, or 18 mg) or matching placebo.

Key facts

Study ID

NCT02177786

Run by

Gilead Sciences

People needed

334

Starts

2014-06-01

Expected to finish

2016-08-01

Last updated by the study team

2019-11-05

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Chase Medcare — Huntsville, Alabama, United States
• Choice Medicine — Toney, Alabama, United States
• Akdhc Medical Research Services, Llc — Peoria, Arizona, United States
• Akdhc Medical Research Services, Llc — Phoenix, Arizona, United States
• Akdhc Medical Research Services, Llc — Phoenix, Arizona, United States
• Akdhc Medical Research Services, Llc — Prescott, Arizona, United States
• Robert J. Bloomberg, MD — Tempe, Arizona, United States
• AKDHC East Office — Tucson, Arizona, United States
• Clinical Research Connections, LLC — Harrisburg, Arkansas, United States
• North America Research Institute — Azusa, California, United States
• California Institute of Renal Research — Chula Vista, California, United States
• California Institute of Renal Research Inc. — El Centro, California, United States
• Renal Consultants Medical Group Granada Hills — Granada Hills, California, United States
• Torrance Clinical Research — Lomita, California, United States
• IMD Medical Group — Los Angeles, California, United States
• Academic Medical Research Institute — Los Angeles, California, United States
• Kidney Research Center — Lynwood, California, United States
• Apex Research of Riverside — Riverside, California, United States
• San Francisco General Hospital — San Francisco, California, United States
• Clearview Medical Research, LLC — Santa Clarita, California, United States
• American Institute of Research — Whittier, California, United States
• Omega Research Consultants — DeBary, Florida, United States
• Creekside Medical Research — DeLand, Florida, United States
• Riverside Clinical Research — Edgewater, Florida, United States
• The University of Alabama at Birmingham (UAB) — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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