Chronotherapy Randomized Controlled Trial

Stopped early · Not applicable · Has a placebo group

Conditions studied: Major Depressive Disorder, Bipolar Depression, Suicidal Ideation

In brief

Chronotherapy is a term that describes therapeutic alterations of sleep wake cycles. Different variations of sleep deprivation, set sleep wake schedules, and types of light therapy have demonstrated efficacy in rapidly treating depression, and suicidal thinking. This study seeks to explore the effect of two different chronotherapuetic protocols on acutely depressed and suicidal inpatients admitted to the Medical University of South Carolina

Key facts

Study ID

NCT02176824

Run by

Medical University of South Carolina

People needed

13

Starts

2014-06-01

Expected to finish

2016-04-07

Last updated by the study team

2019-05-30

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A current episode of non-psychotic major depression
• Currently hospitalized
• Age greater than 18
• If bipolar illness, must not be a mixed state, and must be on a therapeutic dose of a mood stabilizer

You may not qualify if…

• Urine drug screen positive for cocaine, or current alcohol/dependence that requires detox
• current psychosis
• Panic Disorder
• Severe Borderline Personality Disorder
• A history of seizures, uncontrolled severe headaches, stroke, or other neurologic illness that produces either gait abnormalities or lowered seizure threshold
• Medical illness that would make wake therapy intolerable
• Cataracts, glaucoma, or other intrinsic eye condition
• Currently taking light sensitizing medications
• Current pregnancy
• Mental retardation or dementia
• Untreated sleep disorder such as Obstructive Sleep Apnea(OSA), narcolepsy, or periodic limb movement disorder(PLMD) that results in excessive sleepiness
• Currently receiving electroconvulsive therapy (ECT)

Where it is running

• Medical University of South Carolina — Charleston, South Carolina, United States

Full record on ClinicalTrials.gov

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