A Study to Assess the Long-term Safety and Efficacy of Erenumab (AMG 334) in Chronic Migraine Prevention.

Completed · Phase 2

Conditions studied: Treatment for Prevention of Chronic Migraine

In brief

To assess the long-term safety and efficacy of erenumab.

Key facts

Study ID

NCT02174861

Run by

Amgen

People needed

609

Starts

2014-06-30

Expected to finish

2017-05-26

Last updated by the study team

2022-10-12

Who can join

Age: 18 and older, up to 66. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subject has provided informed consent prior to initiation of any study-specific activities/procedures
• Completed the 12-week study visit and did not end IP early during the double-blind treatment period of the AMG 334 20120295 (NCT02066415) parent study, and is appropriate for continued treatment.

You may not qualify if…

• Development of any unstable or clinically significant medical condition, laboratory or electrocardiogram (ECG) abnormality following randomization into the parent study, that in the opinion of the investigator, would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.
• Systolic blood pressure (BP) 160 mm Hg and/or diastolic BP 100 mm Hg or greater at screening/Day 1.
• Subject who used excluded concomitant medications between week 8 and week 12 of the parent study

Where it is running

• Research Site — Palo Alto, California, United States
• Research Site — Santa Monica, California, United States
• Research Site — Sherman Oaks, California, United States
• Research Site — Stamford, Connecticut, United States
• Research Site — Jacksonville, Florida, United States
• Research Site — Orlando, Florida, United States
• Research Site — Palm Beach Gardens, Florida, United States
• Research Site — West Palm Beach, Florida, United States
• Research Site — Atlanta, Georgia, United States
• Research Site — Decatur, Georgia, United States
• Research Site — Indianapolis, Indiana, United States
• Research Site — Pikesville, Maryland, United States
• Research Site — Watertown, Massachusetts, United States
• Research Site — Worcester, Massachusetts, United States
• Research Site — Ann Arbor, Michigan, United States
• Research Site — Springfield, Missouri, United States
• Research Site — St Louis, Missouri, United States
• Research Site — Reno, Nevada, United States
• Research Site — Amherst, New York, United States
• Research Site — Greensboro, North Carolina, United States
• Research Site — Cleveland, Ohio, United States
• Research Site — Philadelphia, Pennsylvania, United States
• Research Site — Nashville, Tennessee, United States
• Research Site — Austin, Texas, United States
• Research Site — Newport Beach, California, United States

Full record on ClinicalTrials.gov

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