Mechanisms and Factors Responsible for the Inhibition of Transposons During Fetal Gonad Development in Humans

Recruiting now

Conditions studied: Medical Termination of Pregnancy, Voluntary Termination of Pregnancy

In brief

This is a single-centre study over 36 months for the inclusion of 30 patients. The selection and inclusion of patients will take place according to the criterion of Medical Termination of Pregnancy at 4 different gestational ages (8-12 weeks of gestation (WG)), 13-16 WG, 17-23 WG and 25-35 WG. The tissue analysed will principally be the gonads, other somatic tissue will also be systematically harvested in parallel (liver and psoas muscle) for control purposes. The gonads will be subjected to molecular biology analyses destined to quantify the expression of transposons and their inhibitors.

Key facts

Study ID

NCT02171845

Run by

Centre Hospitalier Universitaire Dijon

People needed

30

Starts

2014-01-29

Expected to finish

2027-01-01

Last updated by the study team

2022-07-08

Who can join

Age: 0 and older, up to 1. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Couple or mother who has provided written informed consent
• Foetus between 10 and 37 weeks of amenorrhea (WA)
• Male foetus
• Foetus obtained following medical termination of pregnancy or voluntary termination of pregnancy

You may not qualify if…

• persons without national health insurance cover
• foetus presenting aneuploidy
• foetus presenting a malformation of the genital organs

Where it is running

• CHU de DIJON — Dijon, France (enrolling)

Full record on ClinicalTrials.gov

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