SHOCK US STUDY: Fluid Responsiveness in Sepsis Measured by Ultrasonography
Completed
Conditions studied: Sepsis
In brief
The study aim is to examine point-of-care ultrasound findings, reliability, and ease of performance in association with fluid responsiveness for patients with severe sepsis and septic shock. The investigators propose a prospective observational research study of patients presenting to one of three Yale New Haven Hospital emergency departments, York Street Campus, St. Raphael's Campus, and Shoreline Medical Center who meet criteria for sepsis, severe sepsis or septic shock during their emergency department visit.
Key facts
- Study ID
- NCT02170233
- Run by
- Yale University
- People needed
- 65
- Starts
- 2014-08-01
- Expected to finish
- 2016-06-01
- Last updated by the study team
- 2020-01-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All patients age greater than 18 years who meet criteria of sepsis. Septic shock will be defined as those patients with severe sepsis and persistent hypotension (<90mmHg systolic blood pressure) despite a fluid challenge of at least 20cc/kg
- Patients will only be considered eligible for enrollment if the treating physician plans to give at least 1-liter of crystalloid after initial US is performed
- A number (approximately 50 patients) with no symptoms of sepsis will be enrolled to assess measurements in healthy patients. These patients will only have one ultrasound performed for each of the desired study measures.
You may not qualify if…
- Patients unable to provide consent such as non-English speaking patients or patient/health care proxy unable to give consent
- History of significant trauma
- Incarcerated patients
- Failure to complete fluid challenge
- Pericardial disease or heart transplant. Patients with left bundle branch block, pulmonary hypertension, known systolic dysfunction (Ejection Fraction <40%), receiving vasopressors, known moderate or severe valvular dysfunction, and irregular heart rhythms will be enrolled but analyzed separately
Where it is running
- Yale University — New Haven, Connecticut, United States
Full record on ClinicalTrials.gov
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