MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

Recruiting now

Conditions studied: Spinal Injury

In brief

Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology. In some patients that undergo decompressive surgery CSF pressure will be measured invasive perioperative for 24h to find out if functional limitations and structural changes correlate with the spinal pressure and the spinal perfusion when the spinal cord is damaged.

Key facts

Study ID

NCT02170155

Run by

University of Zurich

People needed

350

Starts

2012-12-01

Expected to finish

2026-12-01

Last updated by the study team

2025-12-22

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Cervical injury
• Informed consent
• Age 18-80
• CSM

You may not qualify if…

• No other neurologic disorder and psychiatric disorder
• Seizure
• MRI incompatibility
• Pregnancy

Where it is running

• University of Zurich, Balgrist University Hospital — Zurich, Canton of Zurich, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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