Improving Negative Symptoms of Psychosis In Real-world Environments

Completed · Not applicable

Conditions studied: Schizophrenia

In brief

This study will compare Cognitive Behavioral Social Skills Training-Compensatory Cognitive Training (CBSST-CCT) to a goal-focused supportive contact group to see which intervention better improves symptoms and functioning in people with schizophrenia.

Key facts

Study ID

NCT02170051

Run by

University of California, San Diego

People needed

64

Starts

2014-07-01

Expected to finish

2018-09-03

Last updated by the study team

2021-05-19

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• MUST BE A RESIDENT OF BROADWAY HOME, SAN DIEGO, OR A SERVICE USER OF THE MEETING PLACE, ARETA CROWELL, OR PROJECT ENABLE.
• Voluntary informed consent to participate
• Age 18 to 65
• DSM-IV diagnosis of schizophrenia or schizoaffective disorder based on MINI/SCID
• Moderate-to-severe negative symptoms on the Clinical Assessment Interview for Negative Symptoms (CAINS total score >19)
• ≥ 6th grade reading level on the Wide Range Achievement Test-4 Reading subtest (needed for reading treatment manual)
• Stable on medications; no changes within 3 months prior to enrollment

You may not qualify if…

• Prior CBT, SST, or CCT in the past 5 years
• Severe positive symptoms on the Positive and Negative Syndrome Scale (PANSS Delusions, Disorganization, Hallucinations, or Suspiciousness >5)
• Severe depression on the Calgary Depression Scale for Schizophrenia (CDSS >8)
• Ocular damage/disease/surgery/medications that affect pupil dilation
• DSM-IV alcohol or substance dependence diagnosis in past 6 months based on the MINI or SCID
• Level of care required interferes with outpatient therapy (e.g., hospitalized; severe medical illness) .

Where it is running

• UCSD — La Jolla, California, United States

Full record on ClinicalTrials.gov

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