Oral Nifedipine Versus Oral Labetalol

Completed · Not applicable

Conditions studied: Severe Postpartum Hypertension

In brief

This study's aim is to determine whether oral extended release nifedipine is superior to oral labetolol for the management of postpartum severe hypertension, specifically time to achieve goal blood pressure, and shortening hospital stay. Our hypothesis is that oral extended release nifedipine is superior to oral labetolol for achieving goal blood pressure in the postpartum period.

Key facts

Study ID

NCT02168309

Run by

Cedars-Sinai Medical Center

People needed

50

Starts

2014-06-01

Expected to finish

2016-05-01

Last updated by the study team

2017-12-13

Who can join

Age: 18 and older, up to 100. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years with the abililty to give informed consent
• Intrauterine pregnancy ≥ 32 weeks
• Postpartum
• Persistent postpartum blood pressures ≥ 160/105 on two or more occasions
• Primary obstetrician amenable to starting either study medication in the postpartum period

You may not qualify if…

• Use of other oral antihypertensives concomitantly
• Known AV heart block
• HR <60 or >120
• Absolute contraindication to nifedipine or labetolol such as allergy
• Significant renal disease (Cr >1.5 mg/dL)
• Heart failure
• Moderate persistent or severe asthma
• Preexisting diagnosis of chronic hypertension with medical treatment before delivery
• Chronic hypertension

Where it is running

• Cedars Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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